When treated with RSL3 (0.2 μM for A549, 0.05 μM for H1299) or IKE (2 μM) for 48 h, the SCD mRNA and protein level was slightly increased, which may act as a cellular defense for ferroptosis, while in H89 incubated (30 μM, 48 h) or CREB1-knockdown NSCLC cells, the SCD was significantly diminished (Fig. 4I, J, K). Here, CREB1 is linked to non-small cell lung carcinoma.