It was showed that gallic acid effectively against metastasis in various cancer cell types such as myeloid leukemia, breast cancer and ovarian cancer by modulating multiple signalling pathways, including Akt/mTOR, ERK, MMPs, NFκB, PTEN/Akt/HIF-1α/VEGF pathways [42–44]. This evidence concerns the gene HIF1A and myeloid leukemia.