The following KEGG items were markedly enriched in HCC patients with high USP32 expression: cell behaviors-related pathways (such as ECM-receptor interaction, gap junction and focal adhesion) and molecular signaling pathways (such as ErbB, Calcium and TGF-β signaling pathways) (Fig. 5A and B). The gene discussed is EGFR; the disease is hepatocellular carcinoma.