BNIP3L and familial pancreatic carcinoma: Similarly, in a mouse model of Kras-induced pancreatic cancer [63], Humpton et.al reported that Nix-mediated mitophagy occurred during the stage of pancreatic intraepithelial neoplasia (PanIN), the pre-cancerous lesion of pancreatic cancer, to drive redox robustness and disease progression.