JWH133 activated CB2R regulating the inflammatory response, and subsequently reduced pulmonary fibrosis in mice.The ELISA results showed significantly higher levels of inflammatory markers TNF-α, IL-6, and IL-1β in the serum of the BLM group (Fig. 2A-C), which decreased after the administration of JWH133. The gene discussed is IL6; the disease is pulmonary fibrosis.