All in all, this study manifested that the IMRGs (DOHH, P4HA3 and MMP1) presented good efficiency for predicting GC prognosis, implying that this gene signature relevant to iron metabolism was a promising biomarker in foretelling the prognosis of GC, which would provide new idea on the digging of underlying predictive biomarkers for GC patients. This evidence concerns the gene DOHH and gastric cancer.