Combined with these studies, the prognosis prediction of GC was composed of three iron metabolism related genes, including DOHH, P4HA3 and MMP1. The external verification set further proved the good performance of three gene signature in predicting GC prognosis Jianming Wei et al. found that LC22A17 associated with poor overall survival in GC [45]. The gene discussed is DOHH; the disease is gastric cancer.