The RUNX2 is a master transcription factor in regulating osteoblast differentiation, angiogenesis, cancer metastasis, and, in particular, the fibrosis response.[36, 37, 38] The upregulation of RUNX2 promotes aortic and pulmonary fibrosis.[39, 40] Several fibrosis‐related genes, such as COL1A1 and TIMP1, are regulated by RUNX2.[41, 42] Notably, putative RUNX2‐binding sites are localized in the SLC27A5 promoter, and SLC27A5 expression is repressed by RUNX2, which offers at least one underlying reason for SLC27A5 downregulation in patients with cirrhosis and mice with liver fibrosis. This evidence concerns the gene COL1A1 and cancer.