The LOR estimates from GLMM_histopathology revealed that the proportion of cells in microglia subclusters 2 and 11 exhibited positive associations with hippocampal volume and negative associations with the coverage areas of p-Tau and gliosis, whereas microglia subcluster 8 had a negative association with hippocampal volume and a significant positive association with the coverage areas of p-Tau and gliosis (Fig. 8i and Supplementary Table 6). Here, MAPT is linked to Gliosis.