CHRNB2 and attention deficit-hyperactivity disorder: Annotation of these 12 druggable genes using the Open Target Platform [134] (https://platform.opentargets.org/), which provides multi-level evidence, showed that drugs targeting CHRNB2, such as AZD1446 (interacts with cholinergic neurons), have been in clinical trials for ADHD (e.g., NCT01012375).