After comparing the orthologs of the DEGs with the target genes of nine FDA-approved ADHD drugs recorded in DrugBank (Supplementary Table 7), overlaps were found for DRD2 (fly: Dop2R), HTR1A (fly: 5-HT1A, 5-HT1B), SLC22A5 (fly: CG7084), SLC22A4 (fly: CG7084), ADRB2 (fly: Octbeta2R), ADRA2A (fly: Octalpha2R). The gene discussed is HTR1B; the disease is attention deficit-hyperactivity disorder.