For example, Immune checkpoints such as the programmed cell death-1 (PD-1) receptor are major regulators of T cell exhaustion9 and in vitro PD-1 blockade has been shown to restore helper activity of exhausted CD4+ tumour-infiltrating lymphocytes (TILs) associated with enhanced IFN-γ production10. Here, PDCD1 is linked to neoplasm.