While higher bodyweight and sBP were observed in MC4RTB/TB compared to the MC4R+/+ mice (Supplementary Fig. 1A,B), higher elastin break numbers and AAA incidence (Supplementary Fig. 1C,H,I,K) along with a lower survival rate (Fig. 1J) were found in MC4RTB/TB mice in comparison to MC4R+/+ mice fed a WD. This evidence concerns the gene MC4R and triple-A syndrome.