In a genetic association study conducted by a British group on the data of approximately 0.5 million people available from UK Biobank that focused on 61 nonsynonymous variants found in MC4R, they identified a subset of individuals as carriers for gain-of-function alleles exhibiting lower BMI and obesity, type 2 diabetes, and coronary artery disease9. The gene discussed is MC4R; the disease is type 2 diabetes mellitus.