For example, 47 imageable genes are differently expressed in melanomas sensitive or resistant to PD1-blockade38 (in 34 cases with a p < 0.05, Fig. 5d and Supplementary Data 29), including the matrix metalloproteinase MMP9, the adenosine receptor ADORA1, the glycogen synthase kinase GSK3A, the folate receptor FOLR2 and the transforming growth factor TGFB2 (Fig. 5d). Here, MMP9 is linked to melanoma.