For example, the knockout of PRKDC appears to have a greater sensitizing effect in adrenergic neuroblastoma cell lines (Fig. 4j), whereas KEAP1’s effect on topotecan (Fig. 4k), and HDAC2’s effect on JQAD1 (Fig. 4l), are both sensitizing in mesenchymal-like cell lines (See Supplementary Data Table 9 (final tab) highlighting neuroblastoma relevant combinations for each drug). Here, HDAC2 is linked to neuroblastoma.