Immunologically, IRAP has been shown to be critical in major histocompatibility complex cross presentation53 as well as T-cell receptor signalling54, and in this study we reveal for the first time that IRAP was upregulated in both activated astrocytes and CD11b positive CNS immune cells at 72 h post-stroke, which is suggestive of an inflammatory role for IRAP in the post ischaemic brain. The gene discussed is ITGAM; the disease is stroke disorder.