Interestingly, IRAP inhibitor treatment beginning at 2 h post-stroke significantly increased CD11b within the striatal and cortical core with 0.1 nmol HFI419 (striatum; 122.11 ± 14.72 cells per 0.54 mm2, P < 0.01, cortex; 115.11 ± 21.63 cells per 0.54 mm2, P < 0.01) and striatal core with 1 nmol of HFI419 (126.83 ± 30.13 cells per 0.54 mm2, P < 0.05) compared to sham control (striatum; 40.33 ± 12.3 cells per 0.54 mm2, cortex; 36.83 ± 11.10 cells per 0.54 mm2 Fig. 2G–H). The gene discussed is LNPEP; the disease is Stroke.