At 72 h following stroke, the critically injured ischaemic core demonstrated a reduced GFAP cell count compared to sham however animals treated with 0.1 nmol of HFI419 beginning at 2 h post-stroke demonstrated a greater number of activated astrocytes within the cortical core (178.62 ± 49.62 cells per 0.54 mm2, P < 0.01) compared to the vehicle control (21.81 ± 10.78 cells per 0.54 mm2, Fig. 2E). The gene discussed is GFAP; the disease is Stroke.