Additionally, considering long term IRAP inhibition reverses chronic vessel dysfunction87 and that IRAP inhibition improves learning and memory21,22,24,28,29 as well as reducing seizure susceptibility30,88, there is strong rationale to further explore the effects of chronic IRAP inhibition following stroke in the context of preventing complicating vascular and neurological sequelae. The gene discussed is LNPEP; the disease is stroke disorder.