We have previously shown that global IRAP gene deletion was neuroprotective following transient occlusion of the MCA in mice11 congruous with an earlier report demonstrating that intracarotid administration of angiotensin IV (Ang IV), a competitive albeit non-selective inhibitor of IRAP49, significantly reduced infarct volume, attenuated neurological deficits and increased survival rate in a rat model of embolic stroke (Faure et al. 2006). This evidence concerns the gene AGT and stroke disorder.