Moreover, compared to their respective basal insulin secretion levels, the GSIS of the Ctrl mice increased by 126.1% (p < 0.01), while the GSIS of the T2DM mice increased by 21.7% (p < 0.05), signifying that the GSIS of the T2DM mice dramatically declined by 62.5% compared to the Ctrl mice (Fig. 2G). This evidence concerns the gene INS and type 2 diabetes mellitus.