Regarding other USP30 inhibitors42,76, a N-cyano pyrrolidine compound, FT3967385, was found to significantly increases the ubiquitylation of TOM20 and mitophagy levels, which is comparable to the effects of genetic loss of the Usp30 gene in SHSY5Y neuroblastoma cells, supporting the notion that the catalytic activity of USP30 is important for modulating mitophagy42. The gene discussed is TOMM20; the disease is neuroblastoma.