METTL3 and childhood onset asthma: In addition, although our studies with monocyte-derived macrophages in children with allergic asthma and myeloid cells in animal models have suggested a crucial role for METTL3/m6A modification in the development of allergic asthma mediated by macrophage activation, lung tissue-resident macrophages evidence for this phenotype in childhood asthma is lacking, warranting further studies.