To investigate the relevance of m6A modifications in myeloid cell-mediated allergic asthma, we first crossed Mettl3fl/fl mice with Lyz2-Cre mice to ablate Mettl3 in the myeloid compartment, including macrophages and neutrophils (Supplementary Fig. 1). The gene discussed is METTL3; the disease is allergic asthma.