m6A-seq and MeRIP-qPCR findings indicate that m6A /METTL3/YTHDF3 interactions are involved in the repression of M2 macrophage activation by accelerating the degradation of Pentraxin 3 (PTX3) transcripts, which is widely regarded as a regulator of inflammation and asthma. Here, METTL3 is linked to asthma.