BAX and neuroblastoma: Ku70 and the proapoptotic protein Bax have previously been shown to interact in neuroblastoma cells, with Ku70 acetylation leading to Bax and c-FLIPL release, allowing for c-FLIPL degradation [47] and Bax activation, leading to induction of apoptosis [45, 46, 50, 51] and suggesting that Ku70 acetylation plays a key role in neuroblastoma cell death.