The full scope of the targets of UBE4B ubiquitin ligase activity, however, has not been delineated, and while UBE4B is likely involved in regulating the activity of multiple signaling pathways and networks critical for neuroblastoma cell behavior and tumorigenesis, the mechanistic links between UBE4B ubiquitin ligase activity and neuroblastoma pathogenesis that impact patient outcomes are poorly understood. Here, UBE4B is linked to neuroblastoma.