YAP1 and neoplasm: Collectively, our results obtained across Yap1 mutant Gp130FF and KPT tumor organoids suggests that inhibition of Yap1 activity confers suppression of tumors primarily via an IL11-mediated, tumor cell–intrinsic mechanism that possibly is further augmented by an enhanced anti-tumor immune response suggested from observations in Gp130FF; Yap1KO mice.