We attributed the decreased tumor burden in Gp130FF; Yap1KO mice to decreased cell proliferation as revealed by Ki67 immunohistochemistry, and we observed a concomitant increase in several apoptosis effectors including Bax, cell death activator (Cidea), pleckstrin homology–like domain family A member 3 (Phlda3), the E3 ubiquitin-protein ligase 186 (Rnf186), and tumor protein p53-inducible nuclear protein 1 (Trp53inp1) (Fig 4G and H). This evidence concerns the gene PHLDA3 and neoplasm.