In Yap1KD; Gp130FF tumor organoids, we found reduced transcript levels for Igsf9 (marker for cell proliferation), Cyp2c65, (lipid and glucose metabolism), Ptgr1 and Sult1c2 (metabolite biosynthesis), and Clca1 (mucosal defence) when compared with Yap1WT; Gp130FF tumor. This evidence concerns the gene CLCA1 and neoplasm.