Among the top 18 most enriched pathways were 7 pathways involved in neurotransmitters and other nervous system signaling: opioid signaling, circadian rhythm signaling, glutamate receptor signaling, GABA receptor signaling, amyotrophic lateral sclerosis signaling, neurovascular coupling signaling, and oxytocin in brain signaling (Fig. 8C). Here, OXT is linked to amyotrophic lateral sclerosis.