According to recent mutational analyses of DLBCL and VRL specimens, MYD88 l265P mutation has been reported in a large percentage of examined samples.56 Additionally, Yonese et al. showed that 35% of VRL vitreous samples presented CD79b mutations.57 The MYD88 l265P mutation has also been identified as a potential diagnostic target using aqueous tap. Here, CD79B is linked to diffuse large B-cell lymphoma.