To validate the aptamer-GFET biosensor as a quantitative and precise diagnostic tool, we first focused on determining lower limits of detection for each neurodegenerative disease-associated biomarker (Aβ, Tau, αS) by measuring Dirac shifts after the application of various concentrations of these amyloids suspended in 0.1x PBS buffer (Fig. 3). This evidence concerns the gene MAPT and neurodegenerative disease.