The first association study employed 25 disease phenotypes for their relevance to ROMK function, to Bartter syndrome type II, and to hypertension [9,68], and included phenotypes such as systolic and diastolic blood pressure, serum urea, creatinine, calcium, and phosphate, as well as urine potassium and sodium. The gene discussed is KCNJ1; the disease is hypertensive disorder.