Infection of SARS-CoV-2 greatly induced the expression of many cytokines and chemokines and receptors, while the expression of the majority of cytokines, including IL-1β, IL-2, IL-5, IL-6, IL-26, IL-33, IFNB, IFIT1 and IFIT2, was downregulated by nsp8 expression. The gene discussed is IFNB1; the disease is infection.