In this study, we demonstrated that IOE trigger oxidative stress and liver damage via inhibition of NRF2 expression, which causes liver steatosis, accumulation of ROS, mitochondrial damage, ER stress and upregulation of unfolded protein response, as well as activation of deleterious non canonical inflammasome pathway marked by caspase 11 activation. This evidence concerns the gene NFE2L2 and Hepatic steatosis.