Our previous work found that deleting Rai1 from cortical excitatory neurons using an Emx1Cre allele (Gorski et al., 2002), from the GABAergic neurons using a Gad2Cre allele (Taniguchi et al., 2011), or from astrocytes using a GfapCre allele (Garcia et al., 2004) did not induce SMS-like obesity (Huang et al., 2016). This evidence concerns the gene RAI1 and obesity due to melanocortin 4 receptor deficiency.