APLN and diabetes mellitus: Interestingly, the apelin analogue (pGlu)apelin-13 amide was more effective at lowering triglyceride levels than the incretin mimetics.159 Clinical studies in healthy overweight men also find that apelin enhances insulin sensitivity.160 Studies exploring the ability of apelin to influence glycaemia and vascular health in subjects with increased weight and type 2 diabetes mellitus are in progress (see clinicaltrials.gov: NCT03449251).161