53 Additionally, treatment with ACE inhibitors restores cardiac function in the apelin knockout mouse,53 and in a rodent model of chronic heart failure treatment with an AT1 blocker restored cardiac apelin and apelin receptor expression.38 Elabela also prevents the pressure overload-induced increase in ACE mRNA and protein, restoring the balance of ACE and ACE2.41 This evidence concerns the gene APLNR and congestive heart failure.