It consists of the apelin receptor (encoded by the APLNR gene previously known as APJ) and its two endogenous ligands, apelin and elabela (also known as Toddler).5 The system is a particularly appealing target for cardiovascular disease as it promotes endothelium-dependent vasodilatation, inotropy, lowers blood pressure, and increases aqueous diuresis. This evidence concerns the gene APLNR and cardiovascular disorder.