PIEZO1 and colorectal cancer: Still in DE, we found as top overexpressed genes PIEZO2 – a paralog of PIEZO1 which is involved in colorectal cancer metastases (Sun et al., 2020), SLIT3 – a member of the Slit/Robo pathway, a major regulator of several oncogenic pathways and potential therapeutic target (Gara et al., 2015), and OLFML2B – a potential biomarker for resistance to MEK inhibitors (Hu et al., 2022).