Loss of the Topo IIA (decatenation) checkpoint in G2 correlates with inactivation or loss-of-function of p53 (Doherty et al., 2003; Kaufmann et al., 2002; Lockwood et al., 2022), known to be a common feature of not only these tumor types but more broadly; TP53 is mutated in >50% of all human tumors (Bykov et al., 2018). The gene discussed is TP53; the disease is neoplasm.