Notably, PICH-deficient cell lines are sensitive to Topo IIA inhibition and become binucleated (Nielsen et al., 2015), while PICH depletion in triple-negative breast cancer cells leads to non-disjunction, cytokinesis failure, and ultimately apoptosis after mitotic catastrophe (Huang et al., 2019). This evidence concerns the gene ERCC6L and triple-negative breast carcinoma.