In primary tauopathy conditions, such as frontotemporal lobar degeneration (FTLD), Pick disease, progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and chronic traumatic encephalopathy (CTE), a large number of rare MAPT mutations predispose the development of tau pathology in the central nervous system (CNS)10. This evidence concerns the gene MAPT and Pick disease.