MFN2 and hydrops fetalis: The protective effects of Mfn2 in high-glucose and high-fat medium (HG/HF)-treated cardiomyocytes were blunted by fission activation FFCP, while a Mfn2 activator restored mitochondrial fusion and exerted the protective effects in Mfn2-knockdown CMs, suggesting that imbalanced mitochondrial dynamics induced by down-regulated Mfn2 could be the main cause of cardiac dysfunction in diabetic hearts [106].