The decrease in postmenopausal hormonal exposure may have led to a reduction in breast cancer cases in developed countries.2 The occurrence of breast cancer in men is rare (∼1% of cancers in men and 1% of breast cancer cases are men).6 In this review, we will discuss endocrine treatment of breast cancers and the role of activating transcription factor 2 (ATF2) in cancer and its treatment. The gene discussed is ATF2; the disease is cancer.