In agreement with previous studies, we also observed significant reduction in Annexin-A1 staining in HPV-OPSCC specimens compared to control tissues; nonetheless, discernable Annexin-A1 staining of OPSCC specimens was confined to few clusters of matured, differentiated non-basaloid neoplastic cells (i.e., keratin forming) within the tumor mass. This evidence concerns the gene ANXA1 and neoplasm.