Fourth, glucocorticoids regulate expression of several proteins which, aside from regulating immune and anti-inflammatory responses of glucocorticoids, they are implicated in etiopathogenesis of various cancers; these include the glucocorticoid-induced leucine zipper (GILZ), serum glucocorticoid-regulated kinase-1 (SGK-1) and Annexin-A1 (ANXA1) (13–15). Here, TSC22D3 is linked to cancer.