Fourth, glucocorticoids regulate expression of several proteins which, aside from regulating immune and anti-inflammatory responses of glucocorticoids, they are implicated in etiopathogenesis of various cancers; these include the glucocorticoid-induced leucine zipper (GILZ), serum glucocorticoid-regulated kinase-1 (SGK-1) and Annexin-A1 (ANXA1) (13–15). The gene discussed is SGK1; the disease is cancer.