In relation to tumorigenicity, we are not aware of the impact and/or interaction of GILZ or SGK-1 with either E6 or E7; however, Annexin-A1 is implicated in HPV cervical carcinoma via a mechanism related to preferential E6-mediated degradation of p53 compared to Annexin-A1 (52). The gene discussed is TSC22D3; the disease is cervical carcinoma.