For example, in colorectal carcinoma cells, a variant of GILZ, known as long GILZ, binds to p53 and mouse double minute 2 homolog (MDM2) thereby causing dissociation of p53/MDM2 complex and releasing p53 to exert its tumor suppressor function; MDM2 is the negative regulator of p53 due to formation of MDM2/p53 complex and ultimate induction of ubiquitin-mediated p53 proteosomal degradation (20). This evidence concerns the gene TSC22D3 and colorectal carcinoma.