Second, Annexin-A1staining was observed for cytoplasm, plasma membrane and nuclei of suprabasal cell layers of control specimens while, in the HPV-positive OPSCC specimens, Annexin-A1 staining was confined to nuclear and cytoplasm of clusters of, matured and differentiated, non-basaloid neoplastic cells within the tumor mass. Here, ANXA1 is linked to neoplasm.