Each gene in the risk evaluator, PLXNA1 (Ho, 1988), MARCKSL1 (Egeland et al., 2019), IQGAP3 (Leone et al., 2021), PFN2 (Cui et al., 2016), PON1 (Bobin-Dubigeon et al., 2012), and TAK (Li et al., 2022), has been reported to be associated with the prognosis or progression of cancer. The gene discussed is PON1; the disease is cancer.