Mitochondrially targeted vitamin E succinate (Mito-VES) has high levels of apoptotic activity (Dong et al., 2011) and its anti-tumor mechanism is the rapid production of ROS, with α-TOS acting as a B cell lymphoma 2 (BCL2) homology domain 3 (BH3) mimetic at the molecular level, then effectively sensitizing cancer cells to other drugs and inducing apoptosis by impacting CII. The gene discussed is BCL2; the disease is neoplasm.