BCL2 and neoplasm: The combination of a N-(2 hydroxypropyl) methacrylamide copolymer-based mitochondria-targeted aureomycin delivery system and a mitochondria-distributed Bcl-2 functional conversion peptide NuBCP-9 delivery system (PN9) has been shown to have synergistic effects on tumor regression and metastasis inhibition (Yang et al., 2021).