IAC-S010759(OPi) has same functional backbone but has been attenuated conduction (Molina et al., 2018; Vashisht Gopal et al., 2019), a directed CI inhibitor, was shown to significantly inhibit the growth of melanoma models with multiple MAPKi resistant BRAF mutation in vivo at tolerated doses, and strongly inhibited proliferation and induced apoptosis in OXPHOS-dependent brain cancer and acute myeloid leukemia (AML) models. This evidence concerns the gene BRAF and melanoma.