Saikosaponin A, a triterpenoid saponin isolated from the TCM Bupleurum chinensis, increases GSH levels and SOD activity, reduces MDA levels, upregulates GPX4 expression, downregulates ACSL4 expression, and inhibits ferroptosis in a concentration-dependent manner, thus showing promise as a novel option for AS prevention and treatment (Huang et al., 2022). Here, GPX4 is linked to aortic stenosis.