Another study found that using Lonicerae Japonicae Caulis granules to intervene in gouty arthritis rats, the results showed that the blood uric acid (BUA) level, liver xanthine oxidase (XO) activity, interleukin-1β (IL-1β), matrix metallo proteinase-3 (MMP-3), lipoprotein phospholipase A2 (LP-PLA2) and tumor necrosis factor-α (TNF-α) levels in gouty arthritis rats were significantly reduced, confirming that Lonicerae Japonicae Caulis has anti-inflammatory and analgesic effects (Wang, 2016). Here, TNF is linked to gout.