The maintenance and proliferation of hematopoietic stem cells is known to be supported by hypoxia inducible factor (HIF) within the bone marrow (Takubo et al., 2010), and the induction of HIF1α is known to reduce the cellular uptake of AraC in AML cell lines (Jin et al., 2009). The gene discussed is HIF1A; the disease is acute myeloid leukemia.