Among the 57 children with MIS-C, 46% were diagnosed with acute kidney injury (AKI). Most (58%) were classified as having KDIGO stage 1 AKI. All patients with AKI recovered, and 61% recovered by day two. Only one patient required dialysis. The AKI cohort was older (P<0.001) and had higher median peak values of CRP (P<0.001), IL-6 (P<0.001), ferritin (P<0.001), procalcitonin (P=0.002), left ventricular systolic dysfunction (P<0.001), and lymphopenia (P=0.01) when compared to those without AKI. The gene discussed is IL6; the disease is acute kidney injury.