demonstrated that repeatedly elevated concentrations of inflammation-related proteins such as tumour necrosis factor-a (TNF-α), tumour necrosis factor-a-receptor-1 (TNFR1), interleukin-8 (IL-8), intercellular adhesion molecule-1 (ICAM-1), interleukin-6 (IL-6), E-selectin, and insulin-like growth factor binding protein-1 (IGFBP-1), during the first 2 postnatal weeks (48) led to an increased risk of a cerebral palsy diagnosis 2 years later (49). The gene discussed is IGFBP1; the disease is cerebral palsy.