The qRT-PCR and western blot analyses presented that treatment of LPS-induced ALI rats with QHSG at dosages of 5.5 g/kg, 11 g/kg and 22 g/kg caused significant slump in the mRNA transcriptions and protein translations of NLRP3, ASC, CASP1 and GSDMD in the lung tissues (Figures 6A, B), which was reinforced by IHC assay, showing NLRP3 protein level was markedly lowered in the lung tissues of QHSG-treated ALI rats than that in the model rats (Figure 6C). Here, PYCARD is linked to acute respiratory distress syndrome.