In the present study, with the rat model of LPS-induced ALI, QHSG was unveiled to ameliorate ALI by alleviating the pathological features, reversing the alteration in white blood cell profile and impeding the production of inflammatory cytokines in LPS-induced ALI of the rats through down-regulation of TLR4/NF-κB signaling cascade and inhibition of NLRP3 inflammasome activation. Here, TLR4 is linked to acute respiratory distress syndrome.