CXCL8 and Sepsis: CXCL10 and CXCL8 levels in the blood of septic patients and CXCL2 in mouse models (no CXCL8 gene in mice) correlate positively with septic NET formation, and simultaneous blockade of CXCR1 and CXCR2 with the allosteric inhibitor reparixin prevent NET formation in vitro and in vivo and improved survival in sepsis models (140).