(35) found that Licochalcone A (Lico A) has the ability to hinder the activation of NLRP3 inflammasome and chondrocytes pyroptosis induced by LPS through the Nrf2/HO-1/NF-κB axis, thereby reducing the advancement of osteoarthritis in destabilization of the medial meniscus (DMM)-induced OA mouse model. Here, NFKB1 is linked to osteoarthritis.