Strikingly, the proportion of activated, HLA-DR+, CD4+ T cells (19.0 ± 8.4 vs 27.5 ± 13.5%, p = 0.004, adjusted p = 0.049, Figure 1C), was lower in patients with ANI or MND than in patients without any NCI. The gene discussed is CD4; the disease is asymptomatic neurocognitive impairment.