As an example, genetic glioma models such as PDG-Ink4a, which is induced by RCAS-vectors encoding PDGFB in Nestin-Tv-a; Ink4a/Arf-/- transgenic mice, better recapitulate the mutational landscape of glioma patients compared to the chemically-induced GL261 glioma (29). This evidence concerns the gene PDGFB and central nervous system cancer.