In line with this, treatment of orthotopically implanted KPC119 and Panc02 pancreatic ductal adenocarcinoma (PDAC) models with Nano-sapper, a tumor stroma-targeted calcium phosphate liposome carrying anti-fibrotic α-mangostin and a plasmid encoding LIGHT, enhanced TLS formation and T cell infiltration (27). This evidence concerns the gene TNFSF14 and neoplasm.