Signaling molecules IRF4 and SPIB lie at the nexus of the BCR and TLR signaling pathways promoting ABC DLBCL survival by repressing IRF7, blocking detrimental IFNβ signaling, and transactivating CARD11 which in turn promotes NF-κB signaling and survival of ABC DLBCL (90). The gene discussed is NFKB1; the disease is diffuse large B-cell lymphoma.