Therefore, in the present study, high dose of leptin should negatively impact the prognostic of allergic diseases due to the ability of this adipokine in reducing functional Treg/Tr-1 and TFR cells, CD4 T cell subset implicated in controlling Th2/Th9 and TFH2/TFH13 axis respectively (21, 22). Here, TFRC is linked to allergic disease.