NFKB1 and breast carcinoma: Previous research has demonstrated that Ube2v1-regulated matrix metalloproteinase-1 expression plays a key role in breast cancer cell invasion and metastasis, which requires NF-κB activation (16), and that Ube2v1 promotes CRC metastasis by mediating Sirt1 ubiquitination, which suppresses autophagy epigenetically (6).