Previous research has demonstrated that Ube2v1-regulated matrix metalloproteinase-1 expression plays a key role in breast cancer cell invasion and metastasis, which requires NF-κB activation (16), and that Ube2v1 promotes CRC metastasis by mediating Sirt1 ubiquitination, which suppresses autophagy epigenetically (6). The gene discussed is SIRT1; the disease is colorectal carcinoma.