From KEGG enrichment analysis, the AGE-RAGE, PI3K-Akt, IL-17, MAPK, TNF, EGFR, HIF-1, Apoptosis, Toll-like receptor, Insulin resistance, VEGF, Rap1, NF-kappa B, JAK-STAT, PPAR and Wnt pathway were displayed as the critical signaling participated in the role of QDDHG on DKD. The gene discussed is AKT1; the disease is Insulin resistance.