Studies indicate that the activation of ERK1/2 pathway in the human glomerulopathies was related with renal fibrosis and dysfunction [20], while other study found that the downregulation of phosphorylated ERK1/2 expression level and upregulation of phosphorylated JNK expression levels were associated with apoptosis in rat kidney with diabetes [21]. This evidence concerns the gene MAPK3 and diabetes mellitus.