The analysis results showed that the expression levels of AQP8 (P = 0.022), CXCL-8 (P = 0.042), and ZG16 (P = 0.044) were significantly associated with the prognosis of colon cancer, and the high expression of the above three genes was related to their good prognosis, see Figure 6. This evidence concerns the gene ZG16 and malignant colon neoplasm.